Re: Monkeypox: Single dose of smallpox vaccine offers 78% protection, UKHSA reports

Agreement: 
I Agree
Body: 

Dear Editor,

I understand that the “rules” on reporting vaccine efficacy mean that manufacturers are not permitted to make any claims that they cannot prove.

To a large extent, this makes sense; but it should not prevent experts and journalists from reporting what else is known.

The vaccine is a live-attenuated vaccine, like previous smallpox vaccines. Live-attenuated vaccines generally induce long-term immunity, with priming, so that once immunity has been induced, a follow-up dose leads to a large and very rapid immune response.

Concluding the article “The UKHSA has said that it will continue to investigate the duration of protection from a single dose and two doses of the vaccine.” is a cop-out. Readers have a right to know that, although it has not yet been proven that this particular vaccine will induce long-term immunity, there will be every expectation, based on everything we know about other similar vaccines, that the immunity it induces will be long-lasting.

No competing Interests: 
Yes
The following competing Interests: 
Electronic Publication Date: 
Thursday, November 24, 2022 – 15:19
Workflow State: 
Released
Full Title: 

Re: Monkeypox: Single dose of smallpox vaccine offers 78% protection, UKHSA reports

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Last Name: 
English
First name and middle initial: 
Peter M
Address: 
Epsom, UK
Occupation: 
Public Health Physician (retired)
BMJ: Additional Article Info: 
Rapid response
Twitter: 
Peter M B English

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